Version 5.4
Mus musculus Protein: Qtrt1
Summary
InnateDB Protein IDBP-140324.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Qtrt1
Protein Name queuine tRNA-ribosyltransferase 1
Synonyms 2610028E17Rik; Tgt;
Species Mus musculus
Ensembl Protein ENSMUSP00000002902
InnateDB Gene IDBG-140322 (Qtrt1)
Protein Structure
UniProt Annotation
Function Interacts with QTRTD1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine). {ECO:0000269PubMed:19414587}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19414587}. Mitochondrion {ECO:0000269PubMed:19414587}. Nucleus {ECO:0000269PubMed:19414587}. Note=Weakly associates with mitochondria, possibly via QTRTD1.
Disease Associations
Tissue Specificity Expressed in brain, heart, kidney, liver, ling, skeletal muscle, spleen and testis. {ECO:0000269PubMed:19414587}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008479 queuine tRNA-ribosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0008616 queuosine biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1931441
InterPro IPR002616 tRNA-guanine(15) transglycosylase-like
IPR004803 Queuine tRNA-ribosyltransferase
PFAM PF01702
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JMA2
PhosphoSite PhosphoSite-Q9JMA2
TrEMBL
UniProt Splice Variant
Entrez Gene 60507
UniGene Mm.468540
RefSeq NP_068688
MGI ID
MGI Symbol Qtrt1
OMIM
CCDS CCDS52735
HPRD
IMGT
EMBL AB034632 AK011586 BC044811
GenPept AAH44811 BAA93550 BAB27717

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca