InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bbs12

Summary

InnateDB Protein

IDBP-140382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bbs12

Protein Name

Bardet-Biedl syndrome 12 (human)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052179

InnateDB Gene

IDBG-140380 (Bbs12)

Protein Structure

UniProt Annotation

Function

Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, cilium {ECO:0000250}. Note=Located within the basal body of the primary cilium of differentiating preadipocytes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0042073	intraciliary transport
GO:0042755	eating behavior
GO:0044267	cellular protein metabolic process
GO:0045494	photoreceptor cell maintenance
GO:0045599	negative regulation of fat cell differentiation
GO:0051131	chaperone-mediated protein complex assembly