InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psma6

Summary

InnateDB Protein

IDBP-140649.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psma6

Protein Name

proteasome (prosome, macropain) subunit, alpha type 6

Synonyms

IOTA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021412

InnateDB Gene

IDBG-140647 (Psma6)

Protein Structure

UniProt Annotation

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. {ECO:0000269PubMed:22341445}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22078707}. Nucleus {ECO:0000269PubMed:22078707}. Cytoplasm, P-body {ECO:0000269PubMed:22078707}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies.

Disease Associations

Tissue Specificity

Detected in liver (at protein level). {ECO:0000269PubMed:22341445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	103 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004175	endopeptidase activity
GO:0004298	threonine-type endopeptidase activity
GO:0005515	protein binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007519	skeletal muscle tissue development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005839	proteasome core complex
GO:0005844	polysome
GO:0016363	nuclear matrix
GO:0019773	proteasome core complex, alpha-subunit complex
GO:0030016	myofibril
GO:0030017	sarcomere
GO:0070062	extracellular vesicular exosome