InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpv6

Summary

InnateDB Protein

IDBP-140885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpv6

Protein Name

transient receptor potential cation channel, subfamily V, member 6

Synonyms

Cac; CAT; CaT1; Ecac2; Otrpc3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031902

InnateDB Gene

IDBG-140883 (Trpv6)

Protein Structure

UniProt Annotation

Function

Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO:0000269PubMed:12574114, ECO:0000269PubMed:12601087}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12660155}; Multi-pass membrane protein {ECO:0000269PubMed:12660155}.

Disease Associations

Tissue Specificity

Abundantly expressed in pancreas and placenta, and to a much lesser extend in stomach and kidney. Not detected in intestine. {ECO:0000269PubMed:12765696}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1927259

InterPro

IPR002110 Ankyrin repeat
IPR004729 Transient receptor potential channel
IPR005821 Ion transport domain
IPR008344 Transient receptor potential cation channel subfamily V member 5/6
IPR008345 Transient receptor potential channel, vanilloid 6
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF00520
PF11929
PF12796

PRINTS

PR01415
PR01765
PR01766

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt