InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo3a

Summary

InnateDB Protein

IDBP-140962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo3a

Protein Name

myosin IIIA

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046329

InnateDB Gene

IDBG-140958 (Myo3a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030898	actin-dependent ATPase activity
GO:0043531	ADP binding
GO:0051015	actin filament binding
GO:0060002	plus-end directed microfilament motor activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006468	protein phosphorylation
GO:0007605	sensory perception of sound
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0046777	protein autophosphorylation
GO:0048839	inner ear development
GO:0051491	positive regulation of filopodium assembly

Cellular Component

GO:0001917	photoreceptor inner segment
GO:0016459	myosin complex
GO:0030175	filopodium
GO:0031941	filamentous actin
GO:0032426	stereocilium bundle tip
GO:0032433	filopodium tip

Protein Structure and Domains

PDB ID

MGI:2183924

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001609 Myosin head, motor domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00069
PF07714
PF00063

PRINTS

PR00109
PR00193

PIRSF

SMART

SM00015
SM00242
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt