InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fpr1

Summary

InnateDB Protein

IDBP-141076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fpr1

Protein Name

formyl peptide receptor 1

Synonyms

fMLF-R; FPR; LXA4R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052894

InnateDB Gene

IDBG-141074 (Fpr1)

Protein Structure

UniProt Annotation

Function

High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ. {ECO:0000269PubMed:19497865}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004982	N-formyl peptide receptor activity
GO:0005515	protein binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway