Version 5.4
| Mus musculus Protein: Fpr2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-141097.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Fpr2 | ||||||||
| Protein Name | formyl peptide receptor 2 | ||||||||
| Synonyms | E330010I07Rik; Fpr-rs2; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000065799 | ||||||||
| InnateDB Gene | IDBG-141095 (Fpr2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation. {ECO:0000269PubMed:10477558, ECO:0000269PubMed:12218158, ECO:0000269PubMed:19387439}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Primarily expressed in neutrophils. Not detected in vomeronasal neurons. {ECO:0000269PubMed:10477558, ECO:0000269PubMed:15879124, ECO:0000269PubMed:17237393, ECO:0000269PubMed:19387439, ECO:0000269PubMed:19497865}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1278319 | ||||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR002234 Anaphylatoxin chemotactic receptor family IPR002258 DEZ orphan receptor IPR017452 GPCR, rhodopsin-like, 7TM |
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| PFAM |
PF00001
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| PRINTS |
PR00237
PR01104 PR01126 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | O88536 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 14289 | ||||||||
| UniGene | Mm.416226 | ||||||||
| RefSeq | NP_032065 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Fpr2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS28419 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF071180 AY138248 BC117066 CH466642 | ||||||||
| GenPept | AAC34585 AAI17067 AAN06932 EDL20513 | ||||||||