InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mbip

Summary

InnateDB Protein

IDBP-141133.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mbip

Protein Name

MAP3K12 binding inhibitory protein 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021416

InnateDB Gene

IDBG-141131 (Mbip)

Protein Structure

UniProt Annotation

Function

Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shows a cytoplasmic localization when co- expressed with MAP3K12. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0043966

histone H3 acetylation

Cellular Component

GO:0005634	nucleus
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1918320

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99LQ1

PhosphoSite

PhosphoSite-Q99LQ1

TrEMBL

UniProt Splice Variant

Entrez Gene

217588

UniGene

Mm.403966

RefSeq

NP_663417

MGI ID

MGI Symbol

Mbip

OMIM

CCDS

CCDS25920

HPRD

IMGT

EMBL

AK077125 AK154318 AK171164 BC002277

GenPept

AAH02277 BAC36628 BAE32511 BAE42286