InnateDB Protein
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IDBP-141518.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mboat1
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Protein Name
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membrane bound O-acyltransferase domain containing 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000045441
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InnateDB Gene
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IDBG-141516 (Mboat1)
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Protein Structure
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Function |
Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidylserine (1-acyl-2- hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18287005}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269PubMed:18287005}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in stomach, epididymis, and colon. {ECO:0000269PubMed:18287005}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003674
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molecular_function
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GO:0016746
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transferase activity, transferring acyl groups
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GO:0016747
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transferase activity, transferring acyl groups other than amino-acyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2387184
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InterPro |
IPR004299
Membrane bound O-acyl transferase, MBOAT
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PFAM |
PF03062
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BH98
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PhosphoSite |
PhosphoSite-Q8BH98
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TrEMBL |
Q5T1H3
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UniProt Splice Variant |
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Entrez Gene |
218121
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UniGene |
Mm.89682
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RefSeq |
NP_705774
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MGI ID |
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MGI Symbol |
Mboat1
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OMIM |
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CCDS |
CCDS26414
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HPRD |
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IMGT |
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EMBL |
AB297382
AB305045
AK033388
AK146984
AL450321
AL645749
BC023845
BC024653
CH466561
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GenPept |
AAH23845
AAH24653
BAC28261
BAE27587
BAF93901
BAG12121
CAI24381
CAI24382
CAI24665
CAI24667
EDL32389
EDL32390
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