Version 5.4
Mus musculus Protein: Spc24
Summary
InnateDB Protein IDBP-141542.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spc24
Protein Name SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms 2410030K01Rik; AV109292; Spbc24;
Species Mus musculus
Ensembl Protein ENSMUSP00000096541
InnateDB Gene IDBG-141540 (Spc24)
Protein Structure
UniProt Annotation
Function Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0008150 biological_process
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0031262 Ndc80 complex
Protein Structure and Domains
PDB ID MGI:1914879
InterPro IPR013252 Kinetochore-Ndc80 subunit Spc24
PFAM PF08286
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D083
PhosphoSite PhosphoSite-Q9D083
TrEMBL
UniProt Splice Variant
Entrez Gene 67629
UniGene Mm.429309
RefSeq NP_080558
MGI ID
MGI Symbol Spc24
OMIM
CCDS CCDS40554
HPRD
IMGT
EMBL AK011728 AK031680 AK075950 AK153185 AK167877 BC086683 BC116238
GenPept AAH86683 AAI16239 BAB27804 BAC27510 BAC36077 BAE31786 BAE39891

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca