InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ganab

Summary

InnateDB Protein

IDBP-141550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ganab

Protein Name

alpha glucosidase 2 alpha neutral subunit

Synonyms

AU042638; G2an; GluII; mKIAA0088;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093965

InnateDB Gene

IDBG-141546 (Ganab)

Protein Structure

UniProt Annotation

Function

Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005515	protein binding
GO:0015926	glucosidase activity
GO:0030246	carbohydrate binding
GO:0033919	glucan 1,3-alpha-glucosidase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006491	N-glycan processing

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0017177	glucosidase II complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome