Version 5.4
Homo sapiens Protein: ATF7IP2
Summary
InnateDB Protein IDBP-14198.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATF7IP2
Protein Name activating transcription factor 7 interacting protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000348799
InnateDB Gene IDBG-14196 (ATF7IP2)
Protein Structure
UniProt Annotation
Function Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). {ECO:0000305}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
PFAM PF00041
PF01108
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5U623
PhosphoSite PhosphoSite-Q5U623
TrEMBL H3BUP1
UniProt Splice Variant
Entrez Gene 80063
UniGene Hs.742019
RefSeq XP_006721016
HUGO HGNC:20397
OMIM 613645
CCDS CCDS10540
HPRD
IMGT
EMBL AC022168 AC131649 AK022730 AK093414 AK223492 AK296565 AL832987 AY560615 BC033891 BC069695 BC069713 BC069730 BC137079
GenPept AAH33891 AAH69695 AAH69713 AAH69730 AAI37080 AAT66299 BAB14209 BAC04157 BAD97212 BAG59185 CAH56323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca