InnateDB Protein
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IDBP-141984.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zyx
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Protein Name
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zyxin
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Synonyms
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9530098H06Rik; R75157;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000070427
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InnateDB Gene
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IDBG-141978 (Zyx)
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Protein Structure
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Function |
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1 (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
59 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:103072
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InterPro |
IPR001781
Zinc finger, LIM-type
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PFAM |
PF00412
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PRINTS |
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PIRSF |
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
Q62523
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PhosphoSite |
PhosphoSite-Q62523
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TrEMBL |
Q8CD55
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UniProt Splice Variant |
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Entrez Gene |
22793
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UniGene |
Mm.282303
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RefSeq |
NP_035907
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MGI ID |
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MGI Symbol |
Zyx
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OMIM |
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CCDS |
CCDS20066
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HPRD |
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IMGT |
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EMBL |
AK031415
AK147812
CH466533
X99063
Y07711
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GenPept |
BAC27394
BAE28154
CAA67510
CAA68984
EDL13482
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