InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nub1

Summary

InnateDB Protein

IDBP-142042.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nub1

Protein Name

negative regulator of ubiquitin-like proteins 1

Synonyms

4931404D21Rik; 6330412F12Rik; BS4; NY-REN-18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070265

InnateDB Gene

IDBG-142040 (Nub1)

Protein Structure

UniProt Annotation

Function

Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Predominantly nuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034341	response to interferon-gamma
GO:0034612	response to tumor necrosis factor

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1889001

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR029071 Ubiquitin-related domain

PFAM

PF00627

PRINTS

PIRSF

SMART

SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P54729