InnateDB Protein
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IDBP-142266.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ncoa7
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Protein Name
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nuclear receptor coactivator 7
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000090273
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InnateDB Gene
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IDBG-142264 (Ncoa7)
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Protein Structure
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Function |
Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain and kidney. Weakly expressed in mammary gland, lung and testis. In brain, expression is found in neurons of cerebral cortex, thalamus, hypothalamus, hippocampus, cerebellum, striatum and choroid plexus. {ECO:0000269PubMed:11971969}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
Accession |
GO Term |
GO:0030374
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ligand-dependent nuclear receptor transcription coactivator activity
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GO:0035257
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nuclear hormone receptor binding
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:2444847
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InterPro |
IPR006571
TLDc
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PFAM |
PF07534
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PRINTS |
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PIRSF |
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SMART |
SM00584
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TIGRFAMs |
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Modification |
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SwissProt |
Q6DFV7
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PhosphoSite |
PhosphoSite-Q6DFV7
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TrEMBL |
A9Q6S9
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UniProt Splice Variant |
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Entrez Gene |
211329
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UniGene |
Mm.407282
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RefSeq |
NP_001104737
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MGI ID |
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MGI Symbol |
Ncoa7
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OMIM |
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CCDS |
CCDS48530
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HPRD |
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IMGT |
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EMBL |
AK033503
AK042369
AK128935
AK144324
AK171679
BC049997
BC058572
BC076623
BC080670
CH466540
EF602028
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GenPept |
AAH49997
AAH58572
AAH76623
AAH80670
ABV26008
BAC28325
BAC31241
BAC87660
BAE25834
BAE42607
EDL04854
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