Version 5.4
Mus musculus Protein: Ncoa7
Summary
InnateDB Protein IDBP-142270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncoa7
Protein Name nuclear receptor coactivator 7
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000066741
InnateDB Gene IDBG-142264 (Ncoa7)
Protein Structure
UniProt Annotation
Function Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in brain and kidney. Weakly expressed in mammary gland, lung and testis. In brain, expression is found in neurons of cerebral cortex, thalamus, hypothalamus, hippocampus, cerebellum, striatum and choroid plexus. {ECO:0000269PubMed:11971969}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257 nuclear hormone receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2444847
InterPro IPR004182 GRAM domain
IPR006571 TLDc
IPR018392 LysM domain
PFAM PF02893
PF07534
PF01476
PRINTS
PIRSF
SMART SM00568
SM00584
SM00257
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6DFV7
PhosphoSite PhosphoSite-Q6DFV7
TrEMBL Q3TM55
UniProt Splice Variant
Entrez Gene 211329
UniGene Mm.407282
RefSeq NP_766083
MGI ID
MGI Symbol Ncoa7
OMIM
CCDS CCDS23765
HPRD
IMGT
EMBL AK033503 AK042369 AK128935 AK144324 AK166129 AK171679 BC049997 BC058572 BC076623 BC080670 BC141150
GenPept AAH49997 AAH58572 AAH76623 AAH80670 AAI41151 BAC28325 BAC31241 BAC87660 BAE25834 BAE38587 BAE42607

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca