InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AEBP1

Summary

InnateDB Protein

IDBP-14234.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AEBP1

Protein Name

AE binding protein 1

Synonyms

ACLP;

Species

Homo sapiens

Ensembl Protein

ENSP00000223357

InnateDB Gene

IDBG-14232 (AEBP1)

Protein Structure

UniProt Annotation

Function

May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. {ECO:0000250}.

Subcellular Localization

Isoform 1: Secreted {ECO:0000250}.Isoform 2: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in osteoblast and visceral fat. {ECO:0000269PubMed:8920928}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0004180	carboxypeptidase activity
GO:0004181	metallocarboxypeptidase activity
GO:0005516	calmodulin binding
GO:0008270	zinc ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0007517	muscle organ development

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000834 Peptidase M14, carboxypeptidase A
IPR008969 Carboxypeptidase-like, regulatory domain
IPR008979 Galactose-binding domain-like

PFAM

PF00754
PF00246

PRINTS

PR00765

PIRSF

SMART

SM00231
SM00631

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt