InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Incenp

Summary

InnateDB Protein

IDBP-142672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Incenp

Protein Name

inner centromere protein

Synonyms

2700067E22Rik; AU019509; C130081E20; C77457;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025562

InnateDB Gene

IDBG-142670 (Incenp)

Protein Structure

UniProt Annotation

Function

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1 (By similarity). {ECO:0000250}.

Subcellular Localization

Chromosome, centromere {ECO:0000269PubMed:12584241}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:12584241}. Nucleus {ECO:0000269PubMed:12584241}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:12584241}. Note=Localizes to inner kinetochore. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Localized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters. Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000910	cytokinesis
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000795	synaptonemal complex
GO:0000800	lateral element
GO:0000801	central element
GO:0005721	centromeric heterochromatin
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005874	microtubule
GO:0010369	chromocenter
GO:0030496	midbody
GO:0043234	protein complex