Version 5.4
Mus musculus Protein: Lars
Summary
InnateDB Protein IDBP-142783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lars
Protein Name leucyl-tRNA synthetase
Synonyms 2310045K21Rik; 3110009L02Rik; AW536573; mKIAA1352;
Species Mus musculus
Ensembl Protein ENSMUSP00000095197
InnateDB Gene IDBG-142779 (Lars)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
GO:0006450 regulation of translational fidelity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1913808
InterPro IPR002300 Aminoacyl-tRNA synthetase, class Ia
IPR004493 Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR013155 Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR015413 Methionyl/Leucyl tRNA synthetase
IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase
PFAM PF00133
PF08264
PF09334
PF01406
PRINTS PR00983
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMJ2
PhosphoSite PhosphoSite-Q8BMJ2
TrEMBL Q9CQM4
UniProt Splice Variant
Entrez Gene 107045
UniGene
RefSeq NP_598898
MGI ID
MGI Symbol Lars
OMIM
CCDS CCDS37796
HPRD
IMGT
EMBL AK009823 AK010041 AK030778 AK049472 AK166827 BC052715 CH466528
GenPept AAH52715 BAB26523 BAB26661 BAC27133 BAC33766 BAE39051 EDL10039

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca