InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACR

Summary

InnateDB Protein

IDBP-14294.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACR

Protein Name

acrosin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000216139

InnateDB Gene

IDBG-14292 (ACR)

Protein Structure

UniProt Annotation

Function

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004040	amidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0005537	mannose binding
GO:0008144	drug binding
GO:0008233	peptidase activity
GO:0008270	zinc ion binding
GO:0042806	fucose binding

Biological Process

GO:0002077	acrosome matrix dispersal
GO:0006508	proteolysis
GO:0007190	activation of adenylate cyclase activity
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0007340	acrosome reaction
GO:0007341	penetration of zona pellucida
GO:0032504	multicellular organism reproduction
GO:0048545	response to steroid hormone

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005798	Golgi-associated vesicle
GO:0043159	acrosomal matrix
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR012267 Peptidase S1A, acrosin

PFAM

PF00089

PRINTS

PR00722

PIRSF

PIRSF001141

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References