InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adam9

Summary

InnateDB Protein

IDBP-143129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adam9

Protein Name

a disintegrin and metallopeptidase domain 9 (meltrin gamma)

Synonyms

AU020942; MDC9; mKIAA0021; Mltng;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081048

InnateDB Gene

IDBG-143125 (Adam9)

Protein Structure

UniProt Annotation

Function

Probable zinc protease. May mediate cell-cell or cell- matrix interactions.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding
GO:0043236	laminin binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010042	response to manganese ion
GO:0030216	keratinocyte differentiation
GO:0033627	cell adhesion mediated by integrin
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0033631	cell-cell adhesion mediated by integrin
GO:0034241	positive regulation of macrophage fusion
GO:0034612	response to tumor necrosis factor
GO:0034616	response to laminar fluid shear stress
GO:0042117	monocyte activation
GO:0042542	response to hydrogen peroxide
GO:0050714	positive regulation of protein secretion
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051088	PMA-inducible membrane protein ectodomain proteolysis
GO:0051384	response to glucocorticoid
GO:0051549	positive regulation of keratinocyte migration
GO:0051592	response to calcium ion
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0031233	intrinsic to external side of plasma membrane

Protein Structure and Domains

PDB ID

MGI:105376

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt