Version 5.4
Mus musculus Protein: Ptpn18
Summary
InnateDB Protein IDBP-143218.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptpn18
Protein Name protein tyrosine phosphatase, non-receptor type 18
Synonyms FLP1; HSCF; PTP-HSCF; PTP-K1; Ptpk1;
Species Mus musculus
Ensembl Protein ENSMUSP00000027302
InnateDB Gene IDBG-143216 (Ptpn18)
Protein Structure
UniProt Annotation
Function May be involved in growth and differentiation of hematopoietic cells.
Subcellular Localization Nucleus {ECO:0000269PubMed:8977243}. Cytoplasm {ECO:0000269PubMed:8977243}.
Disease Associations
Tissue Specificity Highest expression in bone marrow. Also expressed in kidney, lung, ovary, spleen, thymus and lymph node. {ECO:0000269PubMed:8695832, ECO:0000269PubMed:8875997, ECO:0000269PubMed:8977243}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:108410
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PRINTS PR00700
PIRSF
SMART SM00194
SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61152
PhosphoSite PhosphoSite-Q61152
TrEMBL
UniProt Splice Variant
Entrez Gene 19253
UniGene
RefSeq NP_035336
MGI ID
MGI Symbol Ptpn18
OMIM
CCDS CCDS14867
HPRD
IMGT
EMBL AK144353 BC008512 U35124 U49853 U52523
GenPept AAB18623 AAB82736 AAC52991 AAH08512 BAE25845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca