InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ecsit

Summary

InnateDB Protein

IDBP-143232.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ecsit

Protein Name

ECSIT homolog (Drosophila)

Synonyms

Sitpec;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096537

InnateDB Gene

IDBG-143228 (Ecsit)

Protein Structure

UniProt Annotation

Function

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development. {ECO:0000269PubMed:10465784, ECO:0000269PubMed:14633973}.Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14633973}. Nucleus {ECO:0000269PubMed:14633973}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in heart, brain, lung, liver, skeletal muscle, kidney and testis. Detected in embryonic mesoderm and epiblast, and in extraembryonic ectoderm. {ECO:0000269PubMed:10465784, ECO:0000269PubMed:14633973}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016651	oxidoreductase activity, acting on NAD(P)H

Biological Process

GO:0001707	mesoderm formation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0030509	BMP signaling pathway
GO:0045087	innate immune response
GO:0051341	regulation of oxidoreductase activity
GO:0055114	oxidation-reduction process