InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sfmbt1

Summary

InnateDB Protein

IDBP-143255.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sfmbt1

Protein Name

Scm-like with four mbt domains 1

Synonyms

4930442N21Rik; 9330180L21Rik; AA536974; Sfmbt; Smr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056744

InnateDB Gene

IDBG-143087 (Sfmbt1)

Protein Structure

UniProt Annotation

Function

Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. {ECO:0000269PubMed:23349461}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the testis, low expression is detected in brain, kidney, heart and lung. Highly expressed in germ cells, where it associates with the synaptic regions of meiotic chromosomes in pachytene stage spermatocytes. {ECO:0000269PubMed:10806358, ECO:0000269PubMed:23592795}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042393	histone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0016568	chromatin modification
GO:0030154	cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048635	negative regulation of muscle organ development

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1859609

InterPro

IPR001660 Sterile alpha motif domain
IPR004092 Mbt repeat
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
IPR021987 Protein of unknown function DUF3588

PFAM

PF02820
PF07647
PF00536
PF12140

PRINTS

PIRSF

SMART

SM00454
SM00561

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JMD1