InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fads1

Summary

InnateDB Protein

IDBP-143405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fads1

Protein Name

fatty acid desaturase 1

Synonyms

0710001O03Rik; A930006B21Rik; AI317215; DSD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010807

InnateDB Gene

IDBG-143403 (Fads1)

Protein Structure

UniProt Annotation

Function

Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3) respectively (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the adrenal gland, liver, brain, and testis, tissues where lipogenesis and steroidogenesis are active. {ECO:0000269PubMed:11792729}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0020037	heme binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006636	unsaturated fatty acid biosynthetic process
GO:0007568	aging
GO:0007584	response to nutrient
GO:0009267	cellular response to starvation
GO:0009744	response to sucrose stimulus
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0019369	arachidonic acid metabolic process
GO:0032868	response to insulin
GO:0033189	response to vitamin A
GO:0035900	response to isolation stress
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle