InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pnpla7

Summary

InnateDB Protein

IDBP-143444.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pnpla7

Protein Name

patatin-like phospholipase domain containing 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044078

InnateDB Gene

IDBG-143442 (Pnpla7)

Protein Structure

UniProt Annotation

Function

Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy (By similarity). Isoform 1 and isoform 2 have equal enzyme activity. Isoform 3 has no enzyme activity. {ECO:0000250, ECO:0000269PubMed:22326266}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Found in the nuclear, mitochondrial, lysosomal, and microsomal fractions. {ECO:0000250}.Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein.Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein.Isoform 3: Endoplasmic reticulum membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 1, isoform 2 and isoform 3 are expressed in white adipose tissue, cardiac muscle, skeletal muscle, and testis. {ECO:0000269PubMed:22326266}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

MGI:2385325

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR002641 Patatin/Phospholipase A2-related
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF01734

PRINTS

PIRSF

SMART

SM00100

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2AJ88