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InnateDB Protein
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IDBP-143468.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppp2r2b
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Protein Name
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protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
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Synonyms
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2900026H06Rik; 6330404L05Rik; E130009M08Rik; PP2A-PR55B; PR55-BETA; SCA12;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000025377
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InnateDB Gene
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IDBG-143462 (Ppp2r2b)
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Protein Structure
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| Function |
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance. {ECO:0000250}.
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| Subcellular Localization |
Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Membrane.Isoform 2: Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Note=Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Expressed in brain, testis, lung and spleen. In the brain, expressed in the cortex, hippocampus and cerebellum (at protein level). {ECO:0000269PubMed:12473071}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
5
[view]
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| Protein-Protein |
4
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
51 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0005515
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protein binding
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GO:0008601
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protein phosphatase type 2A regulator activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1920180
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| InterPro |
IPR000009
Protein phosphatase 2A, regulatory subunit PR55
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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| PFAM |
PF00400
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| PRINTS |
PR00600
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| PIRSF |
PIRSF037309
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| SMART |
SM00320
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q6ZWR4
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| PhosphoSite |
PhosphoSite-Q6ZWR4
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
72930
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| UniGene |
Mm.408724
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| RefSeq |
NP_082668
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| MGI ID |
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| MGI Symbol |
Ppp2r2b
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| OMIM |
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| CCDS |
CCDS29216
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| HPRD |
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| IMGT |
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| EMBL |
AF512670
AF536771
AK013600
AK018119
AK039592
AK148956
BC026686
BC088979
CH466528
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| GenPept |
AAH26686
AAH88979
AAM46987
AAN05641
BAB28921
BAB31079
BAC30395
BAE28701
EDL10024
EDL10025
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Version 5.4