InnateDB Protein
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IDBP-143554.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Thoc6
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Protein Name
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THO complex 6 homolog (Drosophila)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000038137
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InnateDB Gene
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IDBG-143550 (Thoc6)
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Protein Structure
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Function |
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.Plays a role in apoptosis negative control involved in brain development (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
30 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2677480
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q5U4D9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
D3YUL7
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UniProt Splice Variant |
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Entrez Gene |
386612
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UniGene |
Mm.444123
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RefSeq |
NP_001008425
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MGI ID |
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MGI Symbol |
Thoc6
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OMIM |
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CCDS |
CCDS28454
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HPRD |
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IMGT |
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EMBL |
AC154766
BC085131
BC089551
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GenPept |
AAH85131
AAH89551
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