Version 5.4
Mus musculus Protein: Hcfc1r1
Summary
InnateDB Protein IDBP-143664.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hcfc1r1
Protein Name host cell factor C1 regulator 1 (XPO1-dependent)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000024697
InnateDB Gene IDBG-143662 (Hcfc1r1)
Protein Structure
UniProt Annotation
Function Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2663619
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CYQ5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 353502
UniGene Mm.359030
RefSeq NP_861542
MGI ID
MGI Symbol Hcfc1r1
OMIM
CCDS CCDS28455
HPRD
IMGT
EMBL AK013438 BC079865
GenPept AAH79865 BAB28855

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca