InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nefh

Summary

InnateDB Protein

IDBP-143701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nefh

Protein Name

neurofilament, heavy polypeptide

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091061

InnateDB Gene

IDBG-143699 (Nefh)

Protein Structure

UniProt Annotation

Function

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0019901	protein kinase binding
GO:0045735	nutrient reservoir activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0033693	neurofilament bundle assembly
GO:0045104	intermediate filament cytoskeleton organization
GO:0045110	intermediate filament bundle assembly
GO:0048936	peripheral nervous system neuron axonogenesis
GO:0060052	neurofilament cytoskeleton organization
GO:0061564	axon development
GO:1902513	regulation of organelle transport along microtubule