InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnaaf2

Summary

InnateDB Protein

IDBP-143904.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnaaf2

Protein Name

RIKEN cDNA 1110034A24 gene

Synonyms

1110034A24Rik; 2810020C19Rik; AV032410; kintoun; Ktu; mknt; TU54;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021356

InnateDB Gene

IDBG-143902 (Dnaaf2)

Protein Structure

UniProt Annotation

Function

Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in nearly all organs of adult, with higher expression in tissues known to have motile cilia and flagella, such as brain and testis. {ECO:0000269PubMed:19052621}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0010033	response to organic substance
GO:0032526	response to retinoic acid
GO:0060285	cilium-dependent cell motility
GO:0070286	axonemal dynein complex assembly
GO:0071973	bacterial-type flagellum-dependent cell motility