InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hs6st1

Summary

InnateDB Protein

IDBP-144020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hs6st1

Protein Name

heparan sulfate 6-O-sulfotransferase 1

Synonyms

6Ost1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085499

InnateDB Gene

IDBG-144018 (Hs6st1)

Protein Structure

UniProt Annotation

Function

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. {ECO:0000269PubMed:10644753}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in fetal brain and liver. {ECO:0000269PubMed:10644753}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0017095	heparan sulfate 6-O-sulfotransferase activity

Biological Process

GO:0001525	angiogenesis
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO:0048286	lung alveolus development
GO:0048666	neuron development
GO:0060716	labyrinthine layer blood vessel development