Version 5.4
Mus musculus Protein: Lama4
Summary
InnateDB Protein IDBP-144147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lama4
Protein Name laminin, alpha 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000019992
InnateDB Gene IDBG-144145 (Lama4)
Protein Structure
UniProt Annotation
Function Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
Disease Associations
Tissue Specificity Strongly expressed in peripheral nerves, cardiac muscle, fat, dermis, lung stroma, aortic endothelium, endocardium and endothelium of blood vessels in skin and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0001568 blood vessel development
GO:0007155 cell adhesion
GO:0030155 regulation of cell adhesion
GO:0030334 regulation of cell migration
GO:0045995 regulation of embryonic development
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005606 laminin-1 complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:109321
InterPro IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR002049 EGF-like, laminin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009254 Laminin I
IPR010307 Laminin II
PFAM PF00008
PF00054
PF02210
PF00053
PF06008
PF06009
PRINTS
PIRSF
SMART SM00181
SM00210
SM00282
SM00180
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97927
PhosphoSite PhosphoSite-P97927
TrEMBL Q91VV0
UniProt Splice Variant
Entrez Gene 16775
UniGene Mm.483826
RefSeq NP_034811
MGI ID
MGI Symbol Lama4
OMIM
CCDS CCDS35882
HPRD
IMGT
EMBL AK032825 BC008533 BC056176 BC115942 U58950 U59865 U69176 U88352 Y09827
GenPept AAB41840 AAC24725 AAC52982 AAC53178 AAH08533 AAH56176 AAI15943 BAC28043 CAA70970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca