InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddhd2

Summary

InnateDB Protein

IDBP-144161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddhd2

Protein Name

DDHD domain containing 2

Synonyms

2010305K11Rik; mKIAA0725; SAMWD1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033975

InnateDB Gene

IDBG-144159 (Ddhd2)

Protein Structure

UniProt Annotation

Function

Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Golgi apparatus, cis-Golgi network {ECO:0000250}. Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0008150	biological_process
GO:0016042	lipid catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1919358

InterPro

IPR001660 Sterile alpha motif domain
IPR004170 WWE domain
IPR004177 DDHD
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF02825
PF02862
PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80Y98