Version 5.4
Mus musculus Protein: Postn
Summary
InnateDB Protein IDBP-144430.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Postn
Protein Name periostin, osteoblast specific factor
Synonyms A630052E07Rik; AI747096; OSF-2; Osf2; peri; PLF; PN;
Species Mus musculus
Ensembl Protein ENSMUSP00000072773
InnateDB Gene IDBG-144426 (Postn)
Protein Structure
UniProt Annotation
Function Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX. {ECO:0000269PubMed:10404027, ECO:0000269PubMed:20181949}.
Subcellular Localization Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi.
Disease Associations
Tissue Specificity Preferentially expressed in periosteum and periodontal ligament. Also expressed in the developing and adult heart. {ECO:0000269PubMed:10404027, ECO:0000269PubMed:11335131}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008201 heparin binding
Biological Process
GO:0007155 cell adhesion
GO:0008593 regulation of Notch signaling pathway
GO:0009888 tissue development
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID MGI:1926321
InterPro IPR000782 FAS1 domain
IPR011489 EMI domain
IPR016666 TGF beta-induced protein bIGH3/osteoblast-specific factor 2
PFAM PF02469
PF07546
PRINTS
PIRSF PIRSF016553
SMART SM00554
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62009
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 50706
UniGene Mm.402268
RefSeq NP_056599
MGI ID
MGI Symbol Postn
OMIM
CCDS CCDS17351
HPRD
IMGT
EMBL AK030756 BC031449 D13664
GenPept AAH31449 BAA02835 BAC27122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca