InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARL8B

Summary

InnateDB Protein

IDBP-14450.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARL8B

Protein Name

ADP-ribosylation factor-like 8B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000256496

InnateDB Gene

IDBG-14446 (ARL8B)

Protein Structure

UniProt Annotation

Function

May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation (PubMed:15331635). {ECO:0000269PubMed:15331635, ECO:0000269PubMed:16537643}.

Subcellular Localization

Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Note=According to PubMed:15331635, it localizes with microtubules at the spindle mid-zone during mitosis.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:15331635}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0019003	GDP binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0043014	alpha-tubulin binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0007049	cell cycle
GO:0007059	chromosome segregation
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0051301	cell division

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0031902	late endosome membrane
GO:0051233	spindle midzone
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR020849 Small GTPase superfamily, Ras type
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM