InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOP2

Summary

InnateDB Protein

IDBP-14469.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOP2

Protein Name

NOP2 nucleolar protein homolog (yeast)

Synonyms

NOL1; NOP120; NSUN1; p120;

Species

Homo sapiens

Ensembl Protein

ENSP00000313272

InnateDB Gene

IDBG-14467 (NOP2)

Protein Structure

UniProt Annotation

Function

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. {ECO:0000305}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.

Experimentally validated
Total	77 [view]
Protein-Protein	77 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006364	rRNA processing
GO:0008284	positive regulation of cell proliferation
GO:0032259	methylation

Cellular Component

GO:0005730

nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR001678 Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p
IPR002877 Ribosomal RNA methyltransferase FtsJ domain
IPR011023 Nop2p
IPR012586 P120R
IPR023267 RNA (C5-cytosine) methyltransferase
IPR023273 RNA (C5-cytosine) methyltransferase, NOP2
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01189
PF01728
PF08062

PRINTS

PR02008
PR02012

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P46087