InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO1E

Summary

InnateDB Protein

IDBP-14487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO1E

Protein Name

myosin IE

Synonyms

FSGS6; HuncM-IC; MYO1C;

Species

Homo sapiens

Ensembl Protein

ENSP00000288235

InnateDB Gene

IDBG-14485 (MYO1E)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269PubMed:11940582, ECO:0000269PubMed:17257598, ECO:0000269PubMed:20860408}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cell junction {ECO:0000250}. Note=Colocalizes with F-actin (By similarity). In cultured podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with cytoplasmic vesicles, including endocytic clathrin-coated vesicles. Colocalizes with dynamin at cytoplasmic vesicles. {ECO:0000250}.

Disease Associations

Focal segmental glomerulosclerosis 6 (FSGS6) [MIM:614131]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. FSGS6 is a childhood-onset disorder resulting in nephrotic syndrome, which includes massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema. {ECO:0000269PubMed:21697813, ECO:0000269PubMed:21756023}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in the immune system. In the kidney, predominantly expressed in the glomerulus, including podocytes. {ECO:0000269PubMed:21458045, ECO:0000269PubMed:21756023}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0035091	phosphatidylinositol binding
GO:0042623	ATPase activity, coupled
GO:0051015	actin filament binding

Biological Process

GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0003094	glomerular filtration
GO:0006200	ATP catabolic process
GO:0006807	nitrogen compound metabolic process
GO:0006897	endocytosis
GO:0030048	actin filament-based movement
GO:0030097	hemopoiesis
GO:0032836	glomerular basement membrane development
GO:0035166	post-embryonic hemopoiesis
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0072015	glomerular visceral epithelial cell development

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0015629	actin cytoskeleton
GO:0016459	myosin complex
GO:0045334	clathrin-coated endocytic vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001452 SH3 domain
IPR001609 Myosin head, motor domain
IPR010926 Myosin tail 2
IPR011511 Variant SH3 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00018
PF14604
PF00063
PF06017
PF07653

PRINTS

PR00452
PR00193

PIRSF

SMART

SM00015
SM00326
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt