InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grin1

Summary

InnateDB Protein

IDBP-144906.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grin1

Protein Name

glutamate receptor, ionotropic, NMDA1 (zeta 1)

Synonyms

GluN1; GluRdelta1; GluRzeta1; M100174; NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028335

InnateDB Gene

IDBG-144904 (Grin1)

Protein Structure

UniProt Annotation

Function

NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Modulated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	96 [view]
Protein-Protein	96 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005102	receptor binding
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0016594	glycine binding
GO:0016595	glutamate binding
GO:0019899	enzyme binding
GO:0022843	voltage-gated cation channel activity
GO:0035254	glutamate receptor binding
GO:0042165	neurotransmitter binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001661	conditioned taste aversion
GO:0001964	startle response
GO:0001967	suckling behavior
GO:0001975	response to amphetamine
GO:0006810	transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007268	synaptic transmission
GO:0007585	respiratory gaseous exchange
GO:0007611	learning or memory
GO:0007612	learning
GO:0007613	memory
GO:0007616	long-term memory
GO:0008306	associative learning
GO:0008344	adult locomotory behavior
GO:0008355	olfactory learning
GO:0008542	visual learning
GO:0010646	regulation of cell communication
GO:0010942	positive regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0014075	response to amine
GO:0018964	propylene metabolic process
GO:0019233	sensory perception of pain
GO:0021586	pons maturation
GO:0021987	cerebral cortex development
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0035176	social behavior
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0043065	positive regulation of apoptotic process
GO:0043278	response to morphine
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043576	regulation of respiratory gaseous exchange
GO:0045471	response to ethanol
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048167	regulation of synaptic plasticity
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048511	rhythmic process
GO:0048814	regulation of dendrite morphogenesis
GO:0050770	regulation of axonogenesis
GO:0050905	neuromuscular process
GO:0051262	protein tetramerization
GO:0051592	response to calcium ion
GO:0051963	regulation of synapse assembly
GO:0055074	calcium ion homeostasis
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060134	prepulse inhibition
GO:0060179	male mating behavior
GO:0060992	response to fungicide
GO:0070588	calcium ion transmembrane transport
GO:0071287	cellular response to manganese ion
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005887	integral component of plasma membrane
GO:0008021	synaptic vesicle
GO:0009986	cell surface
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0030426	growth cone
GO:0032590	dendrite membrane
GO:0043083	synaptic cleft
GO:0043195	terminal bouton
GO:0043197	dendritic spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

MGI:95819

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR018882 Calmodulin-binding domain C0, NMDA receptor, NR1 subunit
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10562
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt