InnateDB Protein
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IDBP-145035.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hook3
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Protein Name
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hook homolog 3 (Drosophila)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000046788
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InnateDB Gene
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IDBG-145033 (Hook3)
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Protein Structure
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Function |
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex (By similarity). Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:15075236}. Golgi apparatus {ECO:0000269PubMed:15075236}. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, cerebellum, heart, intestine, kidney, liver, lung, skeletal muscle, spleen and stomach (at protein level). {ECO:0000269PubMed:11238449, ECO:0000269PubMed:17140400}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443554
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InterPro |
IPR008636
Hook-related protein family
IPR009053
Prefoldin
IPR010989
t-SNARE
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PFAM |
PF05622
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BUK6
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PhosphoSite |
PhosphoSite-Q8BUK6
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TrEMBL |
Q3UUZ6
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UniProt Splice Variant |
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Entrez Gene |
320191
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UniGene |
Mm.487556
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RefSeq |
NP_997542
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MGI ID |
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MGI Symbol |
Hook3
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OMIM |
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CCDS |
CCDS22206
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HPRD |
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IMGT |
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EMBL |
AK042180
AK054263
AK080377
AK084594
AK137723
AK145149
AY223806
CH466580
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GenPept |
AAO43109
BAC31191
BAC35709
BAC37897
BAC39222
BAE23477
BAE26261
EDL32811
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