Version 5.4
Mus musculus Protein: Man1b1
Summary
InnateDB Protein IDBP-145061.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Man1b1
Protein Name mannosidase, alpha, class 1B, member 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036996
InnateDB Gene IDBG-145059 (Man1b1)
Protein Structure
UniProt Annotation
Function Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2684954
InterPro IPR001382 Glycoside hydrolase, family 47
PFAM PF01532
PRINTS PR00747
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2AJ15
PhosphoSite PhosphoSite-A2AJ15
TrEMBL Q923C1
UniProt Splice Variant
Entrez Gene 227619
UniGene Mm.270798
RefSeq NP_001025154
MGI ID
MGI Symbol Man1b1
OMIM
CCDS CCDS15765
HPRD
IMGT
EMBL AK088523 AL732557 BC006645 BC138550 BC138551 CH466542
GenPept AAH06645 AAI38551 AAI38552 BAC40402 CAM25606 EDL08233

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca