Version 5.4
Homo sapiens Protein: MTMR12
Summary
InnateDB Protein IDBP-14523.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTMR12
Protein Name myotubularin related protein 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000371577
InnateDB Gene IDBG-14517 (MTMR12)
Protein Structure
UniProt Annotation
Function Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location. {ECO:0000269PubMed:11504939, ECO:0000269PubMed:12847286}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12847286}. Note=Localizes to punctate vesicles when associated with MTM1.
Disease Associations
Tissue Specificity Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung. {ECO:0000269PubMed:11504939}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0016311 dephosphorylation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR022587 Myotubularin-associated
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF12578
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9C0I1
PhosphoSite PhosphoSite-Q9C0I1
TrEMBL
UniProt Splice Variant
Entrez Gene 54545
UniGene Hs.481836
RefSeq NP_001035536
HUGO HGNC:18191
OMIM 606501
CCDS CCDS34138
HPRD 05933
IMGT
EMBL AB051469 AK000483 AL833231 AY028703 BC057393
GenPept AAH57393 AAK26171 BAA91195 BAB21773 CAH10604

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca