InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc15a3

Summary

InnateDB Protein

IDBP-145235.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc15a3

Protein Name

solute carrier family 15, member 3

Synonyms

cI-1; Ci1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025646

InnateDB Gene

IDBG-145233 (Slc15a3)

Protein Structure

UniProt Annotation

Function

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed highly in bone marrow derived macrophages, and weakly in spleen and lung. {ECO:0000269PubMed:11004510}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015293	symporter activity

Biological Process

GO:0006810	transport
GO:0006857	oligopeptide transport
GO:0015031	protein transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1929691

InterPro

IPR000109 Proton-dependent oligopeptide transporter family
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter

PFAM

PF00854
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BPX9

PhosphoSite