Version 5.4
Mus musculus Protein: Gimap8
Summary
InnateDB Protein IDBP-145449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gimap8
Protein Name GTPase, IMAP family member 8
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000077350
InnateDB Gene IDBG-145447 (Gimap8)
Protein Structure
UniProt Annotation
Function Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. {ECO:0000269PubMed:16088918}.
Subcellular Localization Endoplasmic reticulum {ECO:0000269PubMed:16088918}. Golgi apparatus {ECO:0000269PubMed:16088918}. Mitochondrion {ECO:0000269PubMed:16088918}. Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity Abundantly expressed in the thymus, spleen, lymph node, followed by the bone marrow and lung. {ECO:0000269PubMed:16088918, ECO:0000269PubMed:16509771}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005525 GTP binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:2685303
InterPro IPR006703 AIG1
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF04548
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q75N62
PhosphoSite PhosphoSite-Q75N62
TrEMBL
UniProt Splice Variant
Entrez Gene 243374
UniGene Mm.86514
RefSeq NP_997651
MGI ID
MGI Symbol Gimap8
OMIM
CCDS CCDS20108
HPRD
IMGT
EMBL AB178029 AJ617674 AK134199 BC137943 BC137944
GenPept AAI37944 AAI37945 BAD16741 BAE22049 CAE85147

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca