InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ap3s1

Summary

InnateDB Protein

IDBP-145485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ap3s1

Protein Name

adaptor-related protein complex 3, sigma 1 subunit

Synonyms

[s]3A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025357

InnateDB Gene

IDBG-145483 (Ap3s1)

Protein Structure

UniProt Annotation

Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000269PubMed:21998198}.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0008089	anterograde axon cargo transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0048490	anterograde synaptic vesicle transport