Version 5.4
Mus musculus Protein: Entpd2
Summary
InnateDB Protein IDBP-145502.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Entpd2
Protein Name ectonucleoside triphosphate diphosphohydrolase 2
Synonyms Cd39l1; NTPDase2;
Species Mus musculus
Ensembl Protein ENSMUSP00000028328
InnateDB Gene IDBG-145500 (Entpd2)
Protein Structure
UniProt Annotation
Function In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent (By similarity). {ECO:0000250}.
Subcellular Localization Isoform Long: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0017110 nucleoside-diphosphatase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0009181 purine ribonucleoside diphosphate catabolic process
GO:0030168 platelet activation
Cellular Component
GO:0005605 basal lamina
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1096863
InterPro IPR000407 Nucleoside phosphatase GDA1/CD39
IPR009010 Aspartate decarboxylase-like domain
PFAM PF01150
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O55026
PhosphoSite PhosphoSite-
TrEMBL Q921R1
UniProt Splice Variant
Entrez Gene 12496
UniGene Mm.482100
RefSeq NP_033979
MGI ID
MGI Symbol Entpd2
OMIM
CCDS CCDS15770
HPRD
IMGT
EMBL AF042811 AK002553 AY376711 BC011241 CH466542 U91511
GenPept AAB81014 AAC24347 AAH11241 AAQ86586 BAB22182 EDL08241

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca