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InnateDB Protein
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IDBP-145510.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gimap4
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Protein Name
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GTPase, IMAP family member 4
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Synonyms
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AU019574; E430007K16Rik; Ian-1; Ian1; Imap4;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000068398
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InnateDB Gene
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IDBG-145506 (Gimap4)
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Protein Structure
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| Function |
Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium (By similarity). May play a role in regulating lymphocyte apoptosis. {ECO:0000250, ECO:0000269PubMed:16569770}.
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| Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:16569770}.
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| Disease Associations |
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| Tissue Specificity |
Detected on splenocytes, B-cells and T-cells (at protein level). {ECO:0000269PubMed:16569770}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
6
[view]
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| Protein-Protein |
5
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
2 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1349656
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| InterPro |
IPR006703
AIG1
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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| PFAM |
PF04548
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q99JY3
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
107526
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| UniGene |
Mm.490512
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| RefSeq |
NP_001230128
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| MGI ID |
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| MGI Symbol |
Gimap4
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| OMIM |
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| CCDS |
CCDS57423
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| HPRD |
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| IMGT |
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| EMBL |
BC005577
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| GenPept |
AAH05577
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Version 5.4