InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr124

Summary

InnateDB Protein

IDBP-145590.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr124

Protein Name

G protein-coupled receptor 124

Synonyms

8430414O08Rik; 9530074E10Rik; mKIAA1531; Tem5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033876

InnateDB Gene

IDBG-145588 (Gpr124)

Protein Structure

UniProt Annotation

Function

Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. {ECO:0000269PubMed:21071672}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Abundantly expressed in tumor vessels as well in the vasculature of the developing embryo. Expression in normal adult tissues is specifically vascular with endothelial expression in CNS, including brain and retina and more widespread pericyte expression in the brain and organs, including the kidney, pancreas and corpus luteum. {ECO:0000269PubMed:11559528, ECO:0000269PubMed:21071672}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0002040	sprouting angiogenesis
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007417	central nervous system development
GO:0010595	positive regulation of endothelial cell migration
GO:0043542	endothelial cell migration
GO:0045765	regulation of angiogenesis
GO:0050920	regulation of chemotaxis
GO:0090210	regulation of establishment of blood-brain barrier
GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1925810

InterPro

IPR000203 GPS motif
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000832 GPCR, family 2, secretin-like
IPR001611 Leucine-rich repeat
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003591 Leucine-rich repeat, typical subtype
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR017981 GPCR, family 2-like

PFAM