InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr44

Summary

InnateDB Protein

IDBP-145610.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr44

Protein Name

G protein-coupled receptor 44

Synonyms

Crth2; Gpr44; Grp45;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036159

InnateDB Gene

IDBG-145608 (Gpr44)

Protein Structure

UniProt Annotation

Function

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001785	prostaglandin J receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004956	prostaglandin D receptor activity
GO:0004958	prostaglandin F receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0019722	calcium-mediated signaling
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway