InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abca3

Summary

InnateDB Protein

IDBP-145991.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abca3

Protein Name

ATP-binding cassette, sub-family A (ABC1), member 3

Synonyms

1810036E22Rik; ABC-C; Abc3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045285

InnateDB Gene

IDBG-145989 (Abca3)

Protein Structure

UniProt Annotation

Function

Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0051384	response to glucocorticoid

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0097208	alveolar lamellar body
GO:0097233	alveolar lamellar body membrane